Personal Info
- Country of residence: Jordan
Information
MALEK ZIHLIF RESUME
NAME: MALEK ZIHLIF
DATE OF BIRTH: 15 NOV 1977
NATIONALITY: JORDANIAN
ADDRESS: 52 B TABARIA STREET
JABAL AL-HUSSEIN
TEL: MOB: 0795518929
HOM: 06-5664956
EMAIL: m.zihlif@ju.edu.jo
TERIATARY EDUCATION
2002 - 2006 DOCTOR OF PHILOSOPHY OF MOLECULAR
PHARMACOLOGY (PhD)
Department of Pharmacology and Physiology
School of Medical Science
Faculty of Medicine
University of New South Wales
2001 - 2002 M.S.c IN BIOPHARMACEUTICAL
School of biotechnology and bimolecular science
Faculty of life Science
University of New South Wales
Sydney, Australia
1995 - 2000 B.S.c IN PHARMACEUTICAL SCIENCE
Faculty of Pharmacy
University of Jordan
Amman, Jordan
OTHER QUALIFICATIONS / MEMBERSHIBS
Nov 2003 MEMBER OF AUSBIOTECH
Australia’s Biotechnology Organisation
March 2003 RADDIATION SAFETY CERTIFICATE
Risk Management Unit
University of New South Wales
RESUME
MALEK ZIHLIF RESUME
Sydney, Australia
Jan 2004 BIOLOGICAL SAFETY AND INFECTION CONTROL
CERTIFICATE
Risk Management Unit
University of New South Wales
Sydney, Australia
RESEARCH EXPERIENCE
1. PhD project: Effect of topoisomersae II poisons and transcription template
inhibitors on global gene expression in human malignant cells.
2. Master degree project: Bisintecalating threading cytotoxins: Evidence for
Bifunctional reaction amongst 9-aminoacridine-4-
carboxamide dimers with piperidine sidechain using
covalently closed circular DNA and agarose gel
electrophoresis.
WORK EXPERIENCE
Dec 2017 Professor of pharmacology
Department Pharmacology
Faculty of Medicine
University of Jordan
Amman, Jordan
Sep 2013 Associated professor of pharmacology
Department Pharmacology
Faculty of Medicine
University of Jordan
Amman, Jordan
Feb 2009- Sep 2013 Assistant professor of pharmacology
Department Pharmacology
Faculty of Medicine
University of Jordan
Amman, Jordan
MALEK ZIHLIF RESUME
Sep 2008 – Jan 2009 Assistant professor of pharmacology
Faculty of Pharmacy
Applied Sciences University
Amman, Jordan
Jan 2007- 2008 Assistant professor of pharmacology
Department Pharmacy
Faculty of Pharmacy
AL-Zytoonah University
Amman, Jordan
March 2003- Aug2005 Teaching assistant
School of Medical Science
Faculty of Medicine
University of New South Wales
Current grants:
Gene Expression Alterations in Chronic Hypoxic MCF7 Breast Cancer Cell Line.
A new approach towards developing a smart and multifunctional peptide based
drug delivery system for selective targeting and treatment of invasive/metastatic
breast cancer
Determining the mechanism of action of a new anti-HER2 drug and investigate its
potential toxicity in animals
PUBLICATIONS
He Z, Bu X, Eleftheriou A, Zihlif M, Qing Z, Stewart BW, Wakelin LP. DNA threading
bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding,
cytotoxicity and cell cycle arrest. Bioorganic & Medicinal Chemistry 2008 Apr
15;16(8):4390-400.
Zihlif M, Catchpoole DR, Stewart BW, Wakelin LP. Effects of DNA threading bis(9-
aminoacridine-4-carboxamides) on global gene expression. Cancer Genomics Proteomics
2009 Nov-Dec;6(6):317-23.
MALEK ZIHLIF RESUME
Zihlif M, Catchpoole DR, Stewart BW, Wakelin LP. Effects of DNA minor groove binding
agents on global gene expression. Cancer Genomics Proteomics. 2010 Nov-Dec;7(6):323-
30.
Zihlif M, Beano H, Barouqa M, Shwaiki S, Naffa R. Some insights into the cellular
responses against doxorubicin and actinomycin D. Jordan Medical Journal.2011, 45(4):
323-330.
Mustafa MS, El-Abadelah MM, Zihlif MA, Naffa RG, Mubarak MS.Synthesis, and
antitumor activity of some N1-(coumarin-7-yl) amidrazones and related congeners.
Molecules. 2012 16(5), 4305-431
Awad ED, El-Abadelah MM, Matar S, Zihlif MA, Naffa RG, Al-Momani EQ, Mubarak
MS. Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-
yl)cinnolines. Molecules. 2011 Dec 28;17(1):227-39.
Zihlif M, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R. Screening the
Antiangiogenic Activity of Medicinal Plants Grown and Sold in Jordan. 2012
Feb;78(3):297-30.
Marwa N. Abu-Aisheh , Mohammad S. Mustafa , Mustafa M. El-Abadelah , Randa G.
Naffa , Said I. Ismail , Malek A. Zihlif, Mutasem O. Taha, Mohammad S. Mubarak.
Synthesis and biological activity assays of some new N1-(flavon-7-yl) amidrazone
derivatives and related congeners. European Journal of Medicinal Chemistry. 2012
Aug;54:65-74.
Zihlif M, Mahmoud I , Ghanem M, Zreikat M , Alrabadi N, Imraish A, Odeh A, Abbas M,
Ismail S. Thymoquinone efficiently inhibits the survival of EBV infected B cells and alters
EBV gene expression. Integrative Cancer Therapies. 2012 Oct 21. (ahead of print)
Zihlif M, Imraish A, Irshaid Y. Frequency of single nucleotide polymorphisms and
duplication of CYP2D6 in the Jordanian population. Genetic Testing and Molecular
Biomarkers. 2012 Oct;16(10):1201-5
S. AbuHammad and Zihlif M. Gene expression alterations in doxorubicin resistant MCF7
breast cancer cell line. Genomics. Genomics 101 (2013) 213 – 220
Abbas MA, Taha MO, Zihlif MA, Disi AM. .β-Caryophyllene causes regression of
endometrial implants in a rat model of endometriosis without affecting fertility. Eur J
Pharmacol. 2013 Jan 23;702(1-3):12-19.
MALEK ZIHLIF RESUME
Zihlif M, Mahafza T, Obeidat NM, Froukh T, Shaban M, Al-Akhras FM, Zihlif N, Naffa
R.Frequency of genetic polymorphisms of ADAM33 and their association with allergic
rhinitis among Jordanians. Gene. 2013 Sep 10.
Zihlif M, Afifi F, Abu-Dahab R, Abdul Majid AM, Somrain H, Saleh MM, Nassar ZD,
Naffa R.The antiangiogenic activities of ethanolic crude extracts of four salvia species.
BMC Complement Altern Med. 2013 Dec 13;13(1):358
H Zalloum, R Tayyem, Y Bustanji, M Zihlif, M Mohammad, TA Rjai, Discovery of new
human epidermal growth factor receptor-2 (HER2) inhibitors for potential use as anticancer
agents via ligand-based pharmacophore modeling. Journal of Molecular Graphics and
Modellingm, 2015, 61, 61-84.
EA Sharieh, AS Awidi, M Ahram, MA Zihlif. Alteration of gene expression in MDA-MB-
453 breast cancer cell line in response to continuous exposure to Trastuzumab. Gene in
press
H Feda'H, MA Zihlif. Gene expression alterations in chronic hypoxic MCF7 breast cancer
cell line. Genomics 2014, 104 (6), 477-481
M Zihlif, N Zihlif, NM Obeidat, T Mahafza, T Froukh, MT Ghanim, Association etween
ADAM33 Polymorphisms and Susceptibility with Adult and Childhood Asthma Among
Jordanians. Genetic testing and molecular biomarkers 2015,18 (11), 767-774
AY Habashneh, MM El‐Abadelah, MA Zihlif, A Imraish, MO Taha. Synthesis and
Antitumor Activities of Some New N1‐(Flavon‐6‐yl) amidrazone Derivatives
Archiv der Pharmazie , 2014, 347 (6), 415-422
MM Abadleh, MM El-Abadelah, SS Sabri, HH Mohammed, MA Zihlif, Synthesis and
Antitumor Activity of Some N2-(Thien-3-yl) amidrazones Zeitschrift für Naturforschung
B , 2014, 69 (7), 811-816.
Malek Zihlif, Nathir M. Obeidat Nadwa Zihlif,Tareq Mahafza, Tawfiq Froukh, Marcel T
Ghanim, Hamza beano, Fatima M AL-Akhras, Randa Naffa. Association between
Gasdermin A and Gasdermin B polymorphisms and susceptibility to adult and childhood
asthma amongst Jordanians. Genetic testing and molecular biomarkers in press.
Haider N. Sultani 1 , Rasha A. ghazal
1, Alaa M. Hayallah2, Loay K.Abdulrahman1, Khaled
Abu-Hammour1, Shatha AbuHammad4, Mutasem O. Taha3, Malek A. Zihlif4 INHIBITORY
EFFECTS OF NEW 1,3-DIETHYL-8-MERCAPTO XANTHINE DERIVATIVES IN HUMAN
MCF7 AND K562 CANCER CELL LINES. Journal of Heterocyclic Chemistry in press
MALEK ZIHLIF RESUME
Al‐zagameem, MM El‐Abadelah, MA Zihlif, RG Naffa, ML Al‐Smadi. Synthesis and
Bioassay of Novel Substituted Pyrano [2, 3‐f] cinnoline‐2‐onesAS Journal of Heterocyclic
Chemistry 2015 in press
RA Al-Balawnih, SM Zmeili, YM Irshaid, MA Zihlif. The effect of licorice drink on
cytochrome P3A6 and P-glycoprotein gene transcription in rabbits. Medicine research 6
(1), 35-40
NH Aboalhaija, MA Zihlif, MO Taha. Discovery of new selective cytotoxic agents against
Bcl-2 expressing cancer cells using ligand-based modeling. Chemico-biological
interactions 250, 12-26
DA AlQudah, MA Zihlif, MO Tah Ligand-based modeling of diverse aryalkylamines
yields new potent P-glycoprotein inhibitors. European journal of medicinal chemistry 110,
204-223. 2017
A Al Maaitah, M Alsmady, S Dmour, D Alsmady, A Al Alwan, M Younis,The Prevalence
and Prognostic Value of BRAFV600E Mutation in Papillary Thyroid Cancer. International
Journal of Human and Health Sciences (IJHHS) 3 (4), 223-230, 2019
HM Hammad, A Imraish, B Azab, AM Best, YS Khader, M Zihlif
Associations of CYP2A6 gene polymorphism with smoking status among Jordanians:
gender-related differencesCurrent Drug Metabolism 20 (9), 765-770, 2019
WJ Al‐Awaida, MA Zihlif, HJ Al‐Ameer, A Sharab, M Akash, The effect of green tea
consumption on the expression of antioxidant‐and inflammation‐related genes induced by
nicotine
Journal of food biochemistry 43 (7), e12874, 2019
S Abudahab, N Hakooz, Y Jarrar, M Al Shahhab, A Saleh, M Zihlif, ..Interethnic
variations of UGT1A1 and UGT1A7 polymorphisms in the Jordanian population. Current
Drug Metabolism 20 (5), 399-410, 2019
IS Mahmoud, A Homsi, HJ Al-Ameer, J Alzyoud, M Darras, M Al Shhab, M Zihlif
Screening the RFX6-DNA binding domain for potential genetic variants in patients with
type 2 diabetes. World Journal of Diabetes 10 (3), 181. 2019
AR Alsayed, M Alzihlif, JAW Al Ramahi. Relevance of vancomycin suceptibility on
patients outcome infected with Staphylococcus aureus The International Arabic Journal of
Antimicrobial Agents 9 (1) 2019
FM Alhawarat, HM Hammad, MS Hijjawi, AS Sharab, DA Abuarqoub, M Zihlif.The
effect of cycling hypoxia on MCF-7 cancer stem cells and the impact of their
MALEK ZIHLIF RESUME
microenvironment on angiogenesis using human umbilical vein endothelial cells
(HUVECs) as a model
PeerJ 7, e5990. 2019
Alshaer, Walhan; Alqudah, Dana A; Wehaibi, Suha; Abuarqoub, Duaa; Zihlif,
Malek; Hatmal, Ma'mon M; Awidi, Abdalla. Downregulation of STAT3, ß-Catenin, and
Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of
Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin. Int J
Mol Sci ; 20(15)2019 Jul 28.
L Baqlouq, M Zihlif, H Hammad, T Thaib. Determining the Relative Gene Expression
Level of Hypoxia Related Genes in Different Cancer Cell Lines. Current Molecular
Pharmacology. 2020
M Zihlif, T Mahafza, T Froukh, FM Al-Akhras, R Alsalman, M Zuriekat, Association
between Gasdermin A and Gasdermin B polymorphisms and allergic rhinitis amongst
Jordanians. Endocrine, Metabolic & Immune Disorders Drug Targets... 2020.
AQ Al Bawab, M Zihlif, Y Jarrar, A Saleh. Continuous Hypoxia and Glucose Metabolism,
The Effects on Genes Expression in Mcf7 Breast Cancer Cell Line. Endocrine, metabolic
& immune disorders drug targets 2020
B Moh’d Al-Rawashdeh, A Sadaalhanjori, E Ali, M ZihlifAssociation of IL-4
Polymorphisms with Allergic Rhinitis in Jordanian Population Medicina 56 (4), 179 . 2020
A Sobiahe, E Hijazi, HJ Al-Ameer, Y Almasri, Y Jarrar, M Zihlif, M Shomaf, (2020)
Arg399Gln XRCC1 Polymorphism and Risk of Squamous Cell Carcinoma of the Head
and Neck in Jordanian Patients.
Asian Pacific Journal of Cancer Prevention 21 (3), 663-665
H Alhawari, Y Jarrar, MA AlKhatib, H Alhawari, M Momani, A Zayed M Zihlif. The
Association of 3-Hydroxy-3-Methylglutaryl-CoA Reductase, Apolipoprotein E, and Solute
Carrier Organic Anion Genetic Variants with Atorvastatin Response among Jordanian.
Life 10 (10), 232, 2020
S Habahbeh, A Imraish, M Zihlif. The crosstalk between adenosine A2B receptor and
insulin signalling in rat skeletal muscle cells. Biologia Futura 71 (3), 283-288, 2020
MALEK ZIHLIF RESUME
R Jabr, M Gharaibeh, AA Zayed, M Zihlif The Association between Apolipoprotein E
Polymorphism and Response to Statins in Group of Hyperlipidemic Patients. Endocrine,
Metabolic & Immune Disorders Drug Targets, 2020
S Abdullah, Y Jarrar, H Alhawari, E Hneet, M Zihlif The Influence Of Endothelial Nitric
Oxide Synthase (Enos) Genetic Polymorphisms On Cholesterol Blood Levels Among Type
2 Diabetic Patients On Atorvastatin Therapy. Endocrine, Metabolic & Immune Disorders
Drug Targets, 2020
ALE Laith, H Saadeh, A Alnaamneh, S Darabseh, ALS Na'meh, M Alzihlif The genetic
landscape of Arab Population, Chechens and Circassians subpopulations from Jordan
through HV1 and HV2 regions of mtDNA. Gene 729, 144314, 2020
CONFRENCES AND PRESENTATION
Gene expression changes in metabolic and hypoxic related genes in response to long term hypoxia
in MCF7 breast cancer cell line.
Presented at “13th Asia- Pacific Oncologists Annual meeting”
Kuala Lumpur,Malaysia 2016
COMPUTER-AIDED MOLECULAR DESIGN AND DISCOVERY OF NEW PGLYCOPROTEIN
INHIBITORS FOLLOWED BY IN VITRO VALIDATION ON
DOXORUBICIN RESISTANT MCF7 CELL-LINE
Presented at 10th Middle East the Best of San Antonio Breast Cancer Symposium
Jeddah Saudi Arabia 2016
مؤتمر مستشفى البشير الدولي الأول Presented at 2016
مؤتمر الأوروبي للسرطان
Hepatocyte nuclear factor 4, alpha (HNF4A): A potential biomarker in MCF7 breast cancer
cell line response to chronic hypoxia
Presented at 40th ESMO European Cancer congress
Vienna, Austria 2015
Gene expression alteration in chronic hypoxic MCF7 breast cancer cell line.
Presented at Eortic – NCI- AACR Symposium on Molecular Targets and Cancer
therapeutics
Barcelona, Spain 2014
MALEK ZIHLIF RESUME
Genetic Expression Alterations in Doxorubicin Resistant MCF7 Breast Cancer Cell-Line
Presented at Eortic – NCI- AACR Symposium on Molecular Targets and Cancer
therapeutics
Boston , USA 2013
GENETIC EXPRESSION ALTERATIONS IN DOXORUBICIN
RESISTANT MCF7 BREAST CANCER CELL-LINE
Presented at 7th Middle East the Best of San Antonio Breast Cancer Symposium
Reyad, Saudí Arabia 2012
EXTRACULLUCULAR
● Excellent computer user. My knowledge extend to include the
following computer packages:
MS-WORD, MS-EXCEL, MS-POWER POINT, Internet
explorer.
● My hobbies vary to include soccer, volleyball, swimming.
● Professional user of the visual aids, such as overhead projectors,
power point presentations.
ACADEMIC REFEREES
Dr Laurence Wakelin
Associate Professor
School of Medical Science
Faculty of Medicine
University of New South Wales
l.wakelin@unsw.aedu.au
(02) 9385-2563
Dr. Stephen Mahler
Senior Lecturer
School of biotechnology and
bimolecular science
Faculty of science
University of New South Wales
s.mahler@unsw.edu.au
(02) 9385-3899
Achievements and Awards
- Years in active
: From
To