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Alaaldin M. Alkilany

Personal Info

  • Country of residence: Jordan
  • Gender: Male
  • Age: 0
  • Curriculum vitae :

Information

Alaaldin M. Alkilany


Department of Pharmaceutics

Faculty of Pharmacy

University of Jordan

Amman-Jordan 11942


00962-79-8675842 (Cell & Viber)

00962-6-5355522 (Fax)

alkilany77@gmail.com

a.alkilany@ju.edu.jo


http://scholar.google.com/citations?user=QW-zKs8AAAAJ&hl=en

http://eacademic.ju.edu.jo/A.AlKilany/Lists/Research%20Interests/AllItems.aspx


Education:

2010-2012 Postdoctoral Fellow

Pharmacology and Toxicology department

Georgia Regents UniversityAugusta, Georgia, USA

2006-2010 PhD., Chemistry (research focus on Nanotechnology)

University of Illinois

Urbana-Champaign, Illinois, USA

1995-2000 B.S. Pharmacy

Jordan University of Science and Technology

Irbid-Jordan


Positions:

2012-present Assistant Professor

Department of Pharmaceutics

University of Jordan

2004-2006 Formulation Team Leader (R&D)

Hikma Pharmaceuticals (http://www.hikma.com)

Amman-Jordan

2000-2004 Formulation Scientist (R&D)

Hikma Pharmaceuticals (http://www.hikma.com)

Amman-Jordan


Visiting Research and Consultation Appointments:

June -Sep 2014 Research visiting scientist

Chemistry Department, University of Illinois at Urbana-

Champaign, Illinois, USA

June -Sep 2012 Research visiting scientist

Chemistry Department, University of Illinois at Urbana-

Champaign, Illinois, USA

2012-present Consultant

Jordan Food & Drug Administration (JFDA)

Pharmaceutical bioequivalence committee


Teaching Experience:

Pharmaceutical Statistics; Pharmaceutical Dispensing; Physical Pharmacy; Industrial

Pharmacy; Seminars in Pharmaceutics; Organic Chemistry (class and lab); General

Chemistry (class and lab)


Pharmaceutical Industry Experience:

• Extensive experience in pharmaceutical pre-formulation, formulation, scale up, and pilot

clinical trials in an FDA-approved pharmaceutical company (http://www.hikma.com).

• Excellent theoretical and practical experience on various pharmaceutical unit operations

such as: granulation, drying, milling, compaction, blending, tablet compression/coating,

and capsule filing.

• Strong experience in writing manufacturing batch records, scientific reports, formulation

protocols, scale-up/production protocols/reports, process validation protocols/reports and

other formulation related documents.

• Strong experience in technology transfer form R&D to production and from production

site to another.

• Knowledge of GMP (good manufacturing practice), GLP (good laboratory practice),

FDA and ICH guidelines, CFR codes, and USP (US Pharmacopeia).


Nanotechnology Technical skills:

• Synthesis and characterization of various types of nanoparticles.

• Modification of nanoparticle surfaces with biomolecules and small molecules, and

quantification of the loading using proper analytical methods.

• Fabrication of drug delivery systems based on anisotropic gold nanoparticles.

• NMR, vibration spectroscopy (FTIR, Raman, SERS), GC-MS, LC-MS, ICP-MS/AES,

XPS, electron microscopy (TEM/Cryo-TEM and SEM), dark/bright field optical

microscopy, fluorescence microscopy, Dynamic Light Scattering (DLS), Zeta potential

analysis, electrophoresis, PCR, western plotting.

• HPLC: operation and method development.

• Synthesis of small organic molecules.

• Cell culture and standard biochemical assays.

• Hands-on experience with animal handling (mice and rats).


Publications:

1. Murphy, C. J.; Gole, A. M.; Hunyadi, S. E.; Stone, J. W.; Sisco, P. N.; Alkilany, A. M.;

Kinard, B. E.; Hankins, P. “Chemical Sensing and Imaging With Metallic Nanorods”

Chemical Communications 2008, 5, 544-557. [Impact Factor* 2010: 5.787]

2. Murphy, C. J.; Gole, A. M.; Stone, J. W.; Sisco, P. N.; Alkilany, A. M.; Goldsmith, E.

C.; Baxter, S. C. “Gold Nanoparticles in Biology: Beyond Toxicity To Cellular Imaging”

Accounts of Chemical Research 2008, 41, 1721-1730. [Impact Factor* 2010: 21.852]

3. Alkilany, A. M.; Frey, R. L.; Ferry, J. L.; Murphy, C. J. “Gold Nanorods as

Nanoadmicelles: 1-Naphthol Partitioning Into a Nanorod-Bound Surfactant Bilayer”

Langmuir 2008, 24, 10235-10239. [Impact Factor*: 4.269]

4. Alkilany, A. M.; Nagaria, P. K.; Hexel, C. R.; Shaw, T. J.; Murphy, C. J.; Wyatt, M. D. “

Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity

and Surface Effects” Small 2009, 5, 701-708. [Impact Factor*: 7.336]

5. Alkilany, A. M.; Murphy, C. J. “Gold Nanoparticles with a Polymerizable Surfactant

Bilayer: Synthesis, Polymerization, and Stability Evaluation” Langmuir 2009, 25, 13874-

13879. [Impact Factor*: 4.269]

6. Alkilany, A. M.; Murphy, C. J. “Toxicity and Cellular Uptake of Gold Nanoparticles:

What Have We Learned So Far? ” Journal of Nanoparticle Research 2010, 12, 2313-

2333. [Impact Factor*: 3.253]

7. Alkilany, A. M.; Nagaria, P. K.; Wyatt, M. D.; Murphy, C. J. “ Cation Exchange on The

Surface of Goldnanorods with a Polymerizable Surfactant: Polymerization, Stability, and

Toxicity Evaluation” Langmuir 2010, 26, 9328-9333. [Impact Factor*: 4.269]

8. Murphy, C. J.; Thompson, L. B.; Alkilany, A. M.; Sisco, P. N.; Boulos, S. P.; Sivapalan,
S. T.; Yang, J. A.; Chernak, D. J.; Huang, J. “ The Many Faces of Gold Nanorods”
Journal of Physical Chemistry Letters 2010, 1, 2867-2875. [Impact Factor*: 3.396]
9. Alkilany, A. M.; Thompson. L. B.; Murphy, C. J.“ Polyelectrolytes Coating Provides a
Facile Route to Suspend Gold Nanorods in Polar Organic Solvents and Hydrophobic
Polymers” ACS Applied Material & Interfaces 2010, 2, 3417-3421. [Impact Factor*:
2.925]
10. Zill, A.; Rutz, A. L.; Kohman, R. E.; Alkilany, A. M.; Murphy, C. J. Kong, H.;
Zimmerman, S. C. “ Clickable Polyglycerol Hyperbranced Polymers and Their
Application to Gold Nanoparticles and Acid-Labile Nanocarriers” Chemical
Communications 2011, 47, 1279-1281. [Impact Factor*: 5.787]
11. Murphy, C. J.; Thompson, L. B.; Chernak, D. J.; Yang, J. A.; Sivapalan, S. T.; Boulos, S.
P.; Huang, J.; Alkilany, A. M.; Sisco, P. N. “Gold Nanorod Crystal Growth: From Seed-
Mediated Synthesis To Nanoscale Sculpting” Current Opinion in Colloid & Interface
Science 2011, 16, 128-134. [Impact Factor*: 6.142]
12. Chandra, S.; Romero, M. J.; Shatanawi, A.; Alkilany, A. M.; Caldwell, R. B.; Caldwell,
R. W. “ Oxidative Species Increase Arginase Activity in Endothelial Cells through
RhoA/Rho Kinase Pathway” British Journal of Pharmacology 2011, 165, 506-519
[Impact Factor*: 4.925]
13. Shatanawi, A.; Alkilany, A. M.; Caldwell, R. B.; Caldwell, R. W. “Angiotensin II Limits
NO Production by Upregulating Arginase through a Mitogen Activated Protein KinaseActivating
Transcription Factor-2 pathway” Circulation 2011; 124: A16962 [Impact
Factor*: 15.221]
14. Alkilany, A. M.; Thompson. L. B.; Boulos, S. P.; Sisco, P. N.; Murphy, C. J. “ Gold
Nanorods: Their Potential For Photothermal Therapeutics and Drug Delivery, Tempered
By The Complexity of Their Biological Interactions” Advanced Drug Delivery Reviews
2012, 64, 190-199 (Invited contribution). [Impact Factor*: 13.577]
15. Dreaden, E. C.; Alkilany, A. M.; Huang, X.; Murphy, C. J.; El-Sayed, M. A. “ The
Golden Age: Gold Nanoparticles for Biomedicine” Chemical Society Reviews 2012, 41,
2740-2779 (Invited critical review, most accessed article in ChemSocRev of the month:
http://blogs.rsc.org/cs/2012/02/02/top-ten-most-accessed-articles-in-december-2 ).
[Impact Factor*: 26.585]
16. Alkilany, A. M.; Shatanawi, A.; Caldwell, R. B.; Caldwell. R. W. “Toxicity and Cellular
Uptake of Gold Nanorods in Vascular Endothelium and Smooth Muscles of Isolated Rat
Blood Vessel: Importance of Surface Modification” Small 2012, 8, 1270-1278 [Impact
Factor*: 7.336]
17. Alkilany, A. M.; Lohse, S. E.; Murphy, C. J. “The Gold Standard: Gold Nanoparticle
Libraries To Understand the Nano-Bio Interface” Accounts of Chemical Research 2013,
46, 650-661 [Impact Factor*: 21.852]
18. Sakhtianchi, R.; Minchin, R. F.; Lee, K. B.; Alkilany, A. M.; Serpooshan, V.;
Mahmoudi, M. “Exocytosis of Nanoparticles From Cells: Role in Cellular Retention and
Toxicity” Advances in Colloid and Interface Science 2013, 201-202, 18-29 [Impact
Factor 6.169]
19. Boulos, S.; Davis, T.; Yang, J.; Lohse, S. E.; Alkilany, A. M.; Holland, l. A.; Murphy, J.
C. “ Nanoparticle-Protein Interactions: A Thermodynamic and Kinetic Study of The
Adsorption of Bovine Serum Albumin to Gold Nanoparticle Surfaces” Langmuir 2013,
29, 14984-14996 [Impact Factor*: 4.19]
20. Alkilany, A. M.; Boulos, S. P. Lohse, S. E.; Thompson, L. B.; Murphy, C. J. “Homing
Peptide-Conjugated Gold Nanorods: The Effect of Amino Acid Sequence Display on
Nanorod Uptake and Cellular Proliferation” Bioconjugate Chemistry 2014, 25, 1162-
1171 [Impact Factor*: 4.58]
21. Alkilany, A. M.; Bani Yaseen A. I.; Park. J. E.; Eller, J. R and Murphy, C. J. “Facile
phase transfer of gold nanoparticles from aqueous solution to organic solvents with
thiolated poly(ethylene glycol)” RSC Advances 2014, 4, 52676-52679 [Impact Factor*:
3.70]
22. Alaaldin, A. M.; Abulateefeh, S. R.; Mills, K. K.; Bani Yaseen, A. I.; Hamaly, M. A.;
Alkhatib, H. S.; Aiedeh, K. M.; Stone, J. W. “Colloidal Stability of Citrate and
Mercaptoacetic Acid Capped Gold Nanoparticles upon Lyophilization: Effect of Capping
Ligand Attachment and Type of Cryoprotectants”. Langmuir 2014, 30, 13799-13808
[Impact Factor*: 4.19]
* Impact factors were obtained via ISI Web of KnowledgeSM (Thompson Reuters-Web of Science
for the year of publication)
Conference Abstracts:
1. Alkilany, A. M.; Burrow, N.; Boulos, S.P.; “Cryo-TEM characterization of gold nanorod
growth in solutions of CTAB with trace Ag+” Oral presentation, 246th National Meeting
of the American Chemical Society, Indianapolis, Indiana, USA (2013).
2. Boulos, S.P.; Alkilany, A.M.; Thompson, L.B.; Lohse, S.E.; Murphy, C.J. “ YSAConjugated
Gold Nanorods as Anti-cancer Therapeutics: Rate of Cellular Uptake and
Photothermal Treatment”. Poster presentation, 243th National Meeting of the American
Chemical Society, San Diego, CA, USA (2011).

3. Shatanawi, A.; Alkilany, A. M.; Caldwell, B. R.; Caldwell, R. W. “Angiotensin II Limits
NO Production by Upregulating Arginase through a Mitogen Activated Protein Kinase-
Activating Transcription Factor-2 pathway”. Oral presentation, American Heart
Association Scientific Section, Orlando, FA, USA (2011).
4. Soto-Ortega1, D.; Paolini, S.; Alkilany, A. M.; Mahtab, R.; Murphy, C. J.; Moss, A. M.
“Negatively Charged Gold Nanoparticles Can Inhibit the Formation of Alzheimer's
Disease Amyloid-β Protein Aggregates in a Mechanism-Specific Fashion”. AIChE, Salt
Lake City, UT, USA (2010).
5. Alkilany, A. M.; Murphy, C. J. “Cation Exchange on The Surface of Gold nanorods with
a Polymerizable Surfactant: Polymerization, Stability, and Toxicity Evaluation”. Poster
presentation, 239th National Meeting of the American Chemical Society, San Francisco,
CA, USA (2010).
6. Alkilany, A. M.; Murphy, C. J. “Gold Nanoparticles with a Polymerizable Surfactant
Bilayer: Synthesis, Polymerization, and Stability Evaluation”. Oral presentation, CNST
annual workshop, the University of Illinois Center for Nanoscale Science and
Technology (CNST), Urbana, IL, USA (2010).
7. Alkilany, A. M.; Nagaria, P. K.; Hexel, C. R.; Shaw, T. J.; Murphy, C. J.; Wyatt, M. D.
“Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity
and Surface Effects”. Poster presentation, 237th National Meeting of the American
Chemical Society, Salt Lake City, UT, USA (2009).
8. Alkilany, A. M.; Frey, R. L.; Ferry, J. L.; Murphy, C. J. “Gold Nanorods as
Nanoadmicelles: 1-Naphthol Partitioning Into a Nanorod-bound Surfactant Bilayer”.
Poster presentation, 235th National Meeting of the American Chemical Society, New
Orleans, LA, USA (2008).
Invited Talks
1. Joint Egyptian-Jordanian Workshop on Technical and Research Collaboration, Dec 2014,
Le Royal Hotel, Amman, Jordan “Fighting Cancer will Nanobullets”.
2. TEDxUJ workshop, Oct 2014, The University of Jordan, Amman, Jordan
“Nanotechnology: An Emerging Discipline”.
3. The 2ed Pharmacy Students Research Training Workshop/ The University of Jordan, Sep
2014, Amman, Jordan “Seminar on Seminars”.
4. The 1st Pharmacy Students Research Training Workshop/ The University of Jordan, Sep
2013, Amman, Jordan “Effective Scientific Presentation:
Critical Tips”.
5. The 15th Scientific Congress of the Association of Pharmacy Colleges in the Arab World
& The 3rd International Conference of The Faculty of Pharmacy / The University of
Jordan, Oct 2012, Amman, Jordan “Tiny Particles with Big Applications: Gold
Nanotechnology”.
6. The 14th Jordanian Pharmaceutical Association (JPA) Conference, Apr 2012, Amman,
Jordan “Biomedical Applications of Gold nanotechnology”.
7. Jordanian Association of Manufacturers of Pharmaceuticals and Medical Appliances
(JAPM), Pharmaceutical Innovation Conference, Feb 2012, Amman, Jordan
“Pharmaceutical Nanotechnology in Jordan: Status & Future Directions”.
8. School of Medicine, Georgia Regents University, Scientific Diversity Day, May 2011,
Augusta, Georgia (USA) “Small Mater Does Mater: Killing cancer with Nano-bullets”

Affiliations:
American Chemical Society
Jordanian Pharmaceutical Association

Training courses and workshops:
Tulip Int’l & Kerry Technical Pharmaceutical Seminar, (May 2014), Millennium Hotel,
Amman, Jordan
STAFF: Academic Development Workshop (Sep 2013), Center of Human Resources
Development, The University of Jordan, Amman-Jordan.
The 5th MENA Bioequivalence Conference (June 2013), The Jordanian Association of
Pharmaceutical Manufacturers, Crowne Plaza Hotel, Amman, Jordan
Alphabetical grading System (Jan 2013), The University of Jordan, Center for Human
Resources Development, Amman-Jordan.
Interactive Ethics Session For Post-Doctoral Scientists (Nov 2011), Georgia Health
Sciences University, Augusta, GA, USA
3rd Advanced Materials Characterization Workshop (Jun 2010), University of Illinois at
Urbana-Champaign, IL, USA
Scientific Writing Workshop (Jan 2010), University of Illinois, IL, USA.
Bioavailability and Bio-Equivalence Studies Workshop (Jan 2005), EJADA, Amman,
Jordan.
Project Management (Mar 2005), Project Management Institute, Amman, Jordan.
Pharmaceutical Tablet Coating Training Course (Dec 2003), Colorcon® Coating School,
Arona, Italy.
Strategic Presentation Workshop (May 2001), Hikma Pharmaceutical Training
Department, Amman, Jordan.

Committee Services
Bioequivalence studies Evaluation Committee, Jordanian Food & Drug Administration
(JFDA), (Mar 2013-present)
Nanotechnology Committee, The University of Jordan, (Oct 2013-present)

References:
Professor Catherine J. Murphy (PhD advisor); phone: 217-333-7680; email:
murphycj@illinois.edu
University of Illinois at Urbana-Champaign
A521 Chemical & Life Sciences Laboratory
600 South Mathews Avenue
Urbana, IL (USA) 61801

Professor Mike Wyatt (PhD committee member); phone: 803-777-0856
wyatt@cop.sc.edu
University of South Carolina
College of Pharmacy
Room 515A, Coker Life Sciences Building
Columbia, SC (USA) 29208
Professor Steven Zimmerman (PhD committee member); phone 217-244-5943
sczimmer@illinois.edu
University of Illinois at Urbana-Champaign
A521 Chemical & Life Sciences Laboratory
600 South Mathews Avenue
Urbana, IL (USA) 61801
Professor R. William Caldwell (postdoctoral research mentor); phone: 706-721-2347
wcaldwel@georgiahealth.edu
Chairman, Pharmacology & Toxicology department
Georgia Regents University
1459 Laney Walker Blvd (CB-3530)
Augusta, GA (USA) 30912
Professor Rula Darwish (Dean of the Faculty of Pharmacy), phone: 00962-79-555-8089
rulad@ju.edu.jo;
Faculty of Pharmacy
The University of Jordan
Amman 11942-Jordan

 

 

 

 

Achievements and Awards

“Speaker recognition award”, Faculty of Pharmacy, The University of Jordan, Sep 2014,
Amman, Jordan.
JPA Recognition Award, 2012, Jordan Pharmaceutical Association (JPA), Amman,
Jordan.
Recipient NIH/NHLBI Post-Doctoral Research Training Grant in Integrative
Cardiovascular Biology, 2010, Georgia Heath Sciences University, Augusta, Georgia,
USA.
Recipient USC Graduate School Research Award, 2007, University of South Carolina,
Columbia, South Carolina, USA.

 

 

 

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