Личная информация
- Страна местожительства: Jordan
Информация
Dr. Alia Shatanawi
Assistant Professor
The University of Jordan
Faculty of Medicine
Department of Pharmacology
Amman-Jordan
962-6-5355000 ext.23458
shatanawi79@gmail.com
a.shatanawi@ju.edu.jo
Education:
2007-2011 Ph.D. with Distinction in Pharmacology, Medical College of Georgia, Georgia Health
Sciences University, Augusta GA. Advisor: Prof. R. William Caldwell
Dissertation title: “Signal Mechanisms in Elevation of Arginase Activity/Expression and
Vascular Dysfunction in Response to Angiotensin II”
1997-2002 Bachelor Degree of Dental Surgery (DDS), Faculty of Dentistry, The University of
Jordan, Amman Jordan
Work Experience:
2012-present Assistant Professor, Department of Pharmacology, Faculty of Medicine,
The University of Jordan
2014- 2015 Visiting Research Scientist, Medical College of Georgia, Georgia Regents
University
2008-2011 Graduate Research Assistant, Department of Pharmacology and
Toxicology, Medical College of Georgia
2007-2008 Graduate Research Assistant, Department of Oral Biology, School of
Dentistry, Medical College of Georgia
2003-2007 Clinical Dentist, private practice, Amman-Jordan
2002-2003 Trainee Clinical Dentist
Queen Alia Military Hospital, Amman-Jordan
Grants and Fellowships:
Mar 2014- present UNESCO-L'OREAL For Women in Science International Fellowship-2014
Dec 2012-Jan 2014 UNESCO-L'OREAL For Women in Science Pan-Arab Regional Fellowship-
2012
Oct 2012-Sep 2014 University of Jordan Research Deanship Grant
July 2010-Jun 2012 American Heart Association Predoctoral Fellowship
Jan 2009-Jun 2010 Multidisciplinary Pre-Doctoral NIH Training Grant
Integrative Cardiovascular Biology T32 NIH/NHLBI
List of Published Research:
1. Bhatta A, Yao L, Toque HA, Shatanawi A, Xu Z, Caldwell RB, Caldwell RW "Angiotensin IIinduced
Arterial Thickening, Fibrosis and Stiffening Involves Elevated Arginase Function".
PLOS One 2015 PloS one 2015;10 (3) e0121727
2. Shatanawi A, Lemtalsi T, Yao L, Patel P, Caldwell RB, Caldwell RW “Angiotensin II Limits
NO Production by Upregulating Arginase through a p38 MAPK - ATF-2 Pathway”, European
Journal of Pharmacology 2015;746 106-114
3. Shatanawi A, Gharaibeh MN, Caldwell RB, Caldwell RW “High Glucose Upregulates Arginase
1 and Decreases Nitric Oxide Production through ATF-2 and c-Jun Transcription Factors”, Life
Science Journal 2014;11(5)
4. Shatanawi A, Lemtalsi T, Caldwell RB, Caldwell RW “High Glucose and Angiotensin II Limit
NO Production through a p38 MAPK-AP1 Transcriptional Regulation of Arginase” Proceedings
of the British Pharmacological Society http://www.pA2online.org/abstracts/Vol11Issue3
5. Shatanawi A, Alkilany AM, Caldwell RB, Caldwell RW “High Glucose limits NO Production
through ATF-2 and c-Jun transcriptional regulation of Arginase” The FASEB Journal, 2012
26:lb524
6. Alkilany AM, Shatanawi A, Kurtz, T, Caldwell RB, Caldwell RW “Toxicity and Cellular
Uptake of Gold Nanorods in Vascular Endothelium and Smooth Muscles of Isolated Rat Blood
Vessel: Importance of Surface Modification” Small. 2012 Apr 23;8(8):1270-8.
7. Chandra S, Romero M, Shatanawi A, Alkilany AM, Caldwell RB, and Caldwell RW.
“Oxidative Species Increase Arginase Activity in Endothelial Cells through RhoA/Rho Kinase
Pathway”. British Journal of Pharmacology. 2012 Jan;165(2):506-19.
8. Shatanawi A, Alkilany AM, Caldwell RB, Caldwell RW “Angiotensin II Limits NO Production
by Upregulating Arginase through a Mitogen Activated Protein Kinase-Activating Transcription
Factor-2 pathway” Circulation 2011; 124: A16962
9. Shatanawi A, Caldwell, RB, Caldwell, RW “Angiotensin II-induced elevation of arginase
activity and impaired vasorelaxation can be prevented by p38 MAPK inhibition” The FASEB
Journal 25, 809.6, 2011
10. Shatanawi A, Romero MJ, Iddings JA, Chandra S, Umapathy NS, Verin AD, Caldwell RB, and
Caldwell RW. “Angiotensin II-Induced Vascular Endothelial Dysfunction through RhoA/Rho
Kinase/p38 Mitogen-Activated Protein Kinase/Arginase Pathway”. American Journal of
Physiology 2011, 300: C1181-1192.
11. Toque HA, Romero MJ, Tostes RC, Shatanawi A, Chandra S, Carneiro ZN, Inscho EW, Webb
RC, Caldwell RB, and Caldwell RW. “p38 Mitogen-activated protein kinase (MAPK) increases
arginase activity and contributes to endothelial dysfunction in corpora cavernosa from
angiotensin-II-treated mice. The Journal of Sexual Medicine 2010, 7: 3857-3867.
12. Shatanawi A, Romero MJ, Chandra S, Yao L, Toque HF, Iddings JA, Caldwell RB, Caldwell
RW.“ p38 MAPK Inhibition Prevents Angiotensin II-Induced Elevation of Arginase Activity and
Impaired Vasorelaxation” FASEB J. April 2010 24. 959.2.
13. Chandra S, Romero MJ, Shatanawi A, Caldwell RB, Caldwell RW. “Peroxynitrite and
Hydrogen Peroxide Increase Arginase Activity through the RhoA/Rho Kinase (RAK) pathway”
FASEB J. April 2010 24. 959.4
14. Torque, HA, Romero MJ, Tostes RC , Shatanawi, A, Iddings JA, Carneiro Z, Inscho E, Webb
CR, Caldwell RB, Caldwell RW. “ Decrease of arginase activity by p38 mitogen-activated
protein kinase inhibition improves corpora cavernosal relaxation in angiotensin-II mice”
Proceedings from the 15th Annual fall Scientific Meeting of the Sexual Medicine Society of North
America San Diego,CA, November 19–21 2009, 7: 6–49
15. Shatanawi A, Romero MJ, Iddings JA, Caldwell RB, Caldwell RW “Angiotensin II Elevates
Arginase Activity via Rho/MAPK Pathways” FASEB J. April 2009 23. 935.1
Affiliations:
2010-present American Heart Association
2008-present American Society for Pharmacology & Experimental Therapeutics (ASPET)
2002-present Jordan Dental Association
References:
1. Prof. William Caldwell, Department of Pharmacology and Toxicology, Medical College of
Georgia, Georgia Regents University. email:wcaldwel@gru.edu Tel: +1706-721-3384
2. Prof. Munir Ghareibeh, Chairman of Department of Pharmacology, Faculty of Medicine,
The University of Jordan, email: mgharaib@ju.edu.jo Tel: +962-6-5355000 ext-23455
3. Prof. John Johnson, Graduate Program Director, Department of Pharmacology and
Toxicology, Medical College of Georgia, Georgia Regents University. email:
JJohnson@gru.edu Tel: +1706-721- 4173.
Достижения и награды
2015 Jury Member, UNESCO-L'OREAL For “Women in Science” Levant and Egypt
Fellowship
Mar 2014 UNESCO-L'OREAL For Women in Science International Fellowship-2014
Dec 2012 UNESCO-L'OREAL For Women in Science Pan-Arab Regional Fellowship-2012
Nov 2011 Graduate School Travel Award, AHA Scientific Sessions
May 2011 Dr. Jerry Buccafusco Graduate Travel Award, Medical College of Georgia
May 2011 Oral presentation award, 1st place in senior division, 10th Annual Pharmacology
& Toxicology Graduate Student Research Symposium, Medical College of
Georgia
May 2010 Oral presentation award, 1st place in junior division, 9th Annual Pharmacology &
Toxicology Graduate Student Research Symposium, Medical College of Georgia
April 2010 ASPET Graduate Student Travel Award, Experimental Biology Conference,
Anaheim, California, USA
May 2009 Oral presentation award, 2st place in junior division, 8th Annual Pharmacology &
Toxicology Graduate Student Research Symposium, Medical College of Georgia
April 2009 Drug Discovery and Development (DDD) Young Investigator Best Abstract
Award, Experimental Biology Conference, New Orleans, Louisiana, USA
April 2009 Graduate School Travel Award, Experimental Biology Conference, New Orleans,
Louisiana, USA
March 2009 Ji Cheng Memorial Award for Excellence in Biomedical Research, Graduate
Research Day, Medical College of Georgia, Augusta, Georgia, USA
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