Личная информация
- Страна местожительства: Jordan
Информация
Alaaldin M. Alkilany
Department of Pharmaceutics
Faculty of Pharmacy
University of Jordan
Amman-Jordan 11942
00962-79-8675842 (Cell & Viber)
00962-6-5355522 (Fax)
alkilany77@gmail.com
a.alkilany@ju.edu.jo
http://scholar.google.com/citations?user=QW-zKs8AAAAJ&hl=en
http://eacademic.ju.edu.jo/A.AlKilany/Lists/Research%20Interests/AllItems.aspx
Education:
2010-2012 Postdoctoral Fellow
Pharmacology and Toxicology department
Georgia Regents UniversityAugusta, Georgia, USA
2006-2010 PhD., Chemistry (research focus on Nanotechnology)
University of Illinois
Urbana-Champaign, Illinois, USA
1995-2000 B.S. Pharmacy
Jordan University of Science and Technology
Irbid-Jordan
Positions:
2012-present Assistant Professor
Department of Pharmaceutics
University of Jordan
2004-2006 Formulation Team Leader (R&D)
Hikma Pharmaceuticals (http://www.hikma.com)
Amman-Jordan
2000-2004 Formulation Scientist (R&D)
Hikma Pharmaceuticals (http://www.hikma.com)
Amman-Jordan
Visiting Research and Consultation Appointments:
June -Sep 2014 Research visiting scientist
Chemistry Department, University of Illinois at Urbana-
Champaign, Illinois, USA
June -Sep 2012 Research visiting scientist
Chemistry Department, University of Illinois at Urbana-
Champaign, Illinois, USA
2012-present Consultant
Jordan Food & Drug Administration (JFDA)
Pharmaceutical bioequivalence committee
Teaching Experience:
Pharmaceutical Statistics; Pharmaceutical Dispensing; Physical Pharmacy; Industrial
Pharmacy; Seminars in Pharmaceutics; Organic Chemistry (class and lab); General
Chemistry (class and lab)
Pharmaceutical Industry Experience:
Extensive experience in pharmaceutical pre-formulation, formulation, scale up, and pilot
clinical trials in an FDA-approved pharmaceutical company (http://www.hikma.com).
Excellent theoretical and practical experience on various pharmaceutical unit operations
such as: granulation, drying, milling, compaction, blending, tablet compression/coating,
and capsule filing.
Strong experience in writing manufacturing batch records, scientific reports, formulation
protocols, scale-up/production protocols/reports, process validation protocols/reports and
other formulation related documents.
Strong experience in technology transfer form R&D to production and from production
site to another.
Knowledge of GMP (good manufacturing practice), GLP (good laboratory practice),
FDA and ICH guidelines, CFR codes, and USP (US Pharmacopeia).
Nanotechnology Technical skills:
Synthesis and characterization of various types of nanoparticles.
Modification of nanoparticle surfaces with biomolecules and small molecules, and
quantification of the loading using proper analytical methods.
Fabrication of drug delivery systems based on anisotropic gold nanoparticles.
NMR, vibration spectroscopy (FTIR, Raman, SERS), GC-MS, LC-MS, ICP-MS/AES,
XPS, electron microscopy (TEM/Cryo-TEM and SEM), dark/bright field optical
microscopy, fluorescence microscopy, Dynamic Light Scattering (DLS), Zeta potential
analysis, electrophoresis, PCR, western plotting.
HPLC: operation and method development.
Synthesis of small organic molecules.
Cell culture and standard biochemical assays.
Hands-on experience with animal handling (mice and rats).
Publications:
1. Murphy, C. J.; Gole, A. M.; Hunyadi, S. E.; Stone, J. W.; Sisco, P. N.; Alkilany, A. M.;
Kinard, B. E.; Hankins, P. “Chemical Sensing and Imaging With Metallic Nanorods”
Chemical Communications 2008, 5, 544-557. [Impact Factor* 2010: 5.787]
2. Murphy, C. J.; Gole, A. M.; Stone, J. W.; Sisco, P. N.; Alkilany, A. M.; Goldsmith, E.
C.; Baxter, S. C. “Gold Nanoparticles in Biology: Beyond Toxicity To Cellular Imaging”
Accounts of Chemical Research 2008, 41, 1721-1730. [Impact Factor* 2010: 21.852]
3. Alkilany, A. M.; Frey, R. L.; Ferry, J. L.; Murphy, C. J. “Gold Nanorods as
Nanoadmicelles: 1-Naphthol Partitioning Into a Nanorod-Bound Surfactant Bilayer”
Langmuir 2008, 24, 10235-10239. [Impact Factor*: 4.269]
4. Alkilany, A. M.; Nagaria, P. K.; Hexel, C. R.; Shaw, T. J.; Murphy, C. J.; Wyatt, M. D. “
Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity
and Surface Effects” Small 2009, 5, 701-708. [Impact Factor*: 7.336]
5. Alkilany, A. M.; Murphy, C. J. “Gold Nanoparticles with a Polymerizable Surfactant
Bilayer: Synthesis, Polymerization, and Stability Evaluation” Langmuir 2009, 25, 13874-
13879. [Impact Factor*: 4.269]
6. Alkilany, A. M.; Murphy, C. J. “Toxicity and Cellular Uptake of Gold Nanoparticles:
What Have We Learned So Far? ” Journal of Nanoparticle Research 2010, 12, 2313-
2333. [Impact Factor*: 3.253]
7. Alkilany, A. M.; Nagaria, P. K.; Wyatt, M. D.; Murphy, C. J. “ Cation Exchange on The
Surface of Goldnanorods with a Polymerizable Surfactant: Polymerization, Stability, and
Toxicity Evaluation” Langmuir 2010, 26, 9328-9333. [Impact Factor*: 4.269]
8. Murphy, C. J.; Thompson, L. B.; Alkilany, A. M.; Sisco, P. N.; Boulos, S. P.; Sivapalan,
S. T.; Yang, J. A.; Chernak, D. J.; Huang, J. “ The Many Faces of Gold Nanorods”
Journal of Physical Chemistry Letters 2010, 1, 2867-2875. [Impact Factor*: 3.396]
9. Alkilany, A. M.; Thompson. L. B.; Murphy, C. J.“ Polyelectrolytes Coating Provides a
Facile Route to Suspend Gold Nanorods in Polar Organic Solvents and Hydrophobic
Polymers” ACS Applied Material & Interfaces 2010, 2, 3417-3421. [Impact Factor*:
2.925]
10. Zill, A.; Rutz, A. L.; Kohman, R. E.; Alkilany, A. M.; Murphy, C. J. Kong, H.;
Zimmerman, S. C. “ Clickable Polyglycerol Hyperbranced Polymers and Their
Application to Gold Nanoparticles and Acid-Labile Nanocarriers” Chemical
Communications 2011, 47, 1279-1281. [Impact Factor*: 5.787]
11. Murphy, C. J.; Thompson, L. B.; Chernak, D. J.; Yang, J. A.; Sivapalan, S. T.; Boulos, S.
P.; Huang, J.; Alkilany, A. M.; Sisco, P. N. “Gold Nanorod Crystal Growth: From Seed-
Mediated Synthesis To Nanoscale Sculpting” Current Opinion in Colloid & Interface
Science 2011, 16, 128-134. [Impact Factor*: 6.142]
12. Chandra, S.; Romero, M. J.; Shatanawi, A.; Alkilany, A. M.; Caldwell, R. B.; Caldwell,
R. W. “ Oxidative Species Increase Arginase Activity in Endothelial Cells through
RhoA/Rho Kinase Pathway” British Journal of Pharmacology 2011, 165, 506-519
[Impact Factor*: 4.925]
13. Shatanawi, A.; Alkilany, A. M.; Caldwell, R. B.; Caldwell, R. W. “Angiotensin II Limits
NO Production by Upregulating Arginase through a Mitogen Activated Protein KinaseActivating
Transcription Factor-2 pathway” Circulation 2011; 124: A16962 [Impact
Factor*: 15.221]
14. Alkilany, A. M.; Thompson. L. B.; Boulos, S. P.; Sisco, P. N.; Murphy, C. J. “ Gold
Nanorods: Their Potential For Photothermal Therapeutics and Drug Delivery, Tempered
By The Complexity of Their Biological Interactions” Advanced Drug Delivery Reviews
2012, 64, 190-199 (Invited contribution). [Impact Factor*: 13.577]
15. Dreaden, E. C.; Alkilany, A. M.; Huang, X.; Murphy, C. J.; El-Sayed, M. A. “ The
Golden Age: Gold Nanoparticles for Biomedicine” Chemical Society Reviews 2012, 41,
2740-2779 (Invited critical review, most accessed article in ChemSocRev of the month:
http://blogs.rsc.org/cs/2012/02/02/top-ten-most-accessed-articles-in-december-2 ).
[Impact Factor*: 26.585]
16. Alkilany, A. M.; Shatanawi, A.; Caldwell, R. B.; Caldwell. R. W. “Toxicity and Cellular
Uptake of Gold Nanorods in Vascular Endothelium and Smooth Muscles of Isolated Rat
Blood Vessel: Importance of Surface Modification” Small 2012, 8, 1270-1278 [Impact
Factor*: 7.336]
17. Alkilany, A. M.; Lohse, S. E.; Murphy, C. J. “The Gold Standard: Gold Nanoparticle
Libraries To Understand the Nano-Bio Interface” Accounts of Chemical Research 2013,
46, 650-661 [Impact Factor*: 21.852]
18. Sakhtianchi, R.; Minchin, R. F.; Lee, K. B.; Alkilany, A. M.; Serpooshan, V.;
Mahmoudi, M. “Exocytosis of Nanoparticles From Cells: Role in Cellular Retention and
Toxicity” Advances in Colloid and Interface Science 2013, 201-202, 18-29 [Impact
Factor 6.169]
19. Boulos, S.; Davis, T.; Yang, J.; Lohse, S. E.; Alkilany, A. M.; Holland, l. A.; Murphy, J.
C. “ Nanoparticle-Protein Interactions: A Thermodynamic and Kinetic Study of The
Adsorption of Bovine Serum Albumin to Gold Nanoparticle Surfaces” Langmuir 2013,
29, 14984-14996 [Impact Factor*: 4.19]
20. Alkilany, A. M.; Boulos, S. P. Lohse, S. E.; Thompson, L. B.; Murphy, C. J. “Homing
Peptide-Conjugated Gold Nanorods: The Effect of Amino Acid Sequence Display on
Nanorod Uptake and Cellular Proliferation” Bioconjugate Chemistry 2014, 25, 1162-
1171 [Impact Factor*: 4.58]
21. Alkilany, A. M.; Bani Yaseen A. I.; Park. J. E.; Eller, J. R and Murphy, C. J. “Facile
phase transfer of gold nanoparticles from aqueous solution to organic solvents with
thiolated poly(ethylene glycol)” RSC Advances 2014, 4, 52676-52679 [Impact Factor*:
3.70]
22. Alaaldin, A. M.; Abulateefeh, S. R.; Mills, K. K.; Bani Yaseen, A. I.; Hamaly, M. A.;
Alkhatib, H. S.; Aiedeh, K. M.; Stone, J. W. “Colloidal Stability of Citrate and
Mercaptoacetic Acid Capped Gold Nanoparticles upon Lyophilization: Effect of Capping
Ligand Attachment and Type of Cryoprotectants”. Langmuir 2014, 30, 13799-13808
[Impact Factor*: 4.19]
* Impact factors were obtained via ISI Web of KnowledgeSM (Thompson Reuters-Web of Science
for the year of publication)
Conference Abstracts:
1. Alkilany, A. M.; Burrow, N.; Boulos, S.P.; “Cryo-TEM characterization of gold nanorod
growth in solutions of CTAB with trace Ag+” Oral presentation, 246th National Meeting
of the American Chemical Society, Indianapolis, Indiana, USA (2013).
2. Boulos, S.P.; Alkilany, A.M.; Thompson, L.B.; Lohse, S.E.; Murphy, C.J. “ YSAConjugated
Gold Nanorods as Anti-cancer Therapeutics: Rate of Cellular Uptake and
Photothermal Treatment”. Poster presentation, 243th National Meeting of the American
Chemical Society, San Diego, CA, USA (2011).
3. Shatanawi, A.; Alkilany, A. M.; Caldwell, B. R.; Caldwell, R. W. “Angiotensin II Limits
NO Production by Upregulating Arginase through a Mitogen Activated Protein Kinase-
Activating Transcription Factor-2 pathway”. Oral presentation, American Heart
Association Scientific Section, Orlando, FA, USA (2011).
4. Soto-Ortega1, D.; Paolini, S.; Alkilany, A. M.; Mahtab, R.; Murphy, C. J.; Moss, A. M.
“Negatively Charged Gold Nanoparticles Can Inhibit the Formation of Alzheimer's
Disease Amyloid-β Protein Aggregates in a Mechanism-Specific Fashion”. AIChE, Salt
Lake City, UT, USA (2010).
5. Alkilany, A. M.; Murphy, C. J. “Cation Exchange on The Surface of Gold nanorods with
a Polymerizable Surfactant: Polymerization, Stability, and Toxicity Evaluation”. Poster
presentation, 239th National Meeting of the American Chemical Society, San Francisco,
CA, USA (2010).
6. Alkilany, A. M.; Murphy, C. J. “Gold Nanoparticles with a Polymerizable Surfactant
Bilayer: Synthesis, Polymerization, and Stability Evaluation”. Oral presentation, CNST
annual workshop, the University of Illinois Center for Nanoscale Science and
Technology (CNST), Urbana, IL, USA (2010).
7. Alkilany, A. M.; Nagaria, P. K.; Hexel, C. R.; Shaw, T. J.; Murphy, C. J.; Wyatt, M. D.
“Cellular Uptake and Cytotoxicity of Gold Nanorods: Molecular Origin of Cytotoxicity
and Surface Effects”. Poster presentation, 237th National Meeting of the American
Chemical Society, Salt Lake City, UT, USA (2009).
8. Alkilany, A. M.; Frey, R. L.; Ferry, J. L.; Murphy, C. J. “Gold Nanorods as
Nanoadmicelles: 1-Naphthol Partitioning Into a Nanorod-bound Surfactant Bilayer”.
Poster presentation, 235th National Meeting of the American Chemical Society, New
Orleans, LA, USA (2008).
Invited Talks
1. Joint Egyptian-Jordanian Workshop on Technical and Research Collaboration, Dec 2014,
Le Royal Hotel, Amman, Jordan “Fighting Cancer will Nanobullets”.
2. TEDxUJ workshop, Oct 2014, The University of Jordan, Amman, Jordan
“Nanotechnology: An Emerging Discipline”.
3. The 2ed Pharmacy Students Research Training Workshop/ The University of Jordan, Sep
2014, Amman, Jordan “Seminar on Seminars”.
4. The 1st Pharmacy Students Research Training Workshop/ The University of Jordan, Sep
2013, Amman, Jordan “Effective Scientific Presentation:
Critical Tips”.
5. The 15th Scientific Congress of the Association of Pharmacy Colleges in the Arab World
& The 3rd International Conference of The Faculty of Pharmacy / The University of
Jordan, Oct 2012, Amman, Jordan “Tiny Particles with Big Applications: Gold
Nanotechnology”.
6. The 14th Jordanian Pharmaceutical Association (JPA) Conference, Apr 2012, Amman,
Jordan “Biomedical Applications of Gold nanotechnology”.
7. Jordanian Association of Manufacturers of Pharmaceuticals and Medical Appliances
(JAPM), Pharmaceutical Innovation Conference, Feb 2012, Amman, Jordan
“Pharmaceutical Nanotechnology in Jordan: Status & Future Directions”.
8. School of Medicine, Georgia Regents University, Scientific Diversity Day, May 2011,
Augusta, Georgia (USA) “Small Mater Does Mater: Killing cancer with Nano-bullets”
Affiliations:
American Chemical Society
Jordanian Pharmaceutical Association
Training courses and workshops:
Tulip Int’l & Kerry Technical Pharmaceutical Seminar, (May 2014), Millennium Hotel,
Amman, Jordan
STAFF: Academic Development Workshop (Sep 2013), Center of Human Resources
Development, The University of Jordan, Amman-Jordan.
The 5th MENA Bioequivalence Conference (June 2013), The Jordanian Association of
Pharmaceutical Manufacturers, Crowne Plaza Hotel, Amman, Jordan
Alphabetical grading System (Jan 2013), The University of Jordan, Center for Human
Resources Development, Amman-Jordan.
Interactive Ethics Session For Post-Doctoral Scientists (Nov 2011), Georgia Health
Sciences University, Augusta, GA, USA
3rd Advanced Materials Characterization Workshop (Jun 2010), University of Illinois at
Urbana-Champaign, IL, USA
Scientific Writing Workshop (Jan 2010), University of Illinois, IL, USA.
Bioavailability and Bio-Equivalence Studies Workshop (Jan 2005), EJADA, Amman,
Jordan.
Project Management (Mar 2005), Project Management Institute, Amman, Jordan.
Pharmaceutical Tablet Coating Training Course (Dec 2003), Colorcon® Coating School,
Arona, Italy.
Strategic Presentation Workshop (May 2001), Hikma Pharmaceutical Training
Department, Amman, Jordan.
Committee Services
Bioequivalence studies Evaluation Committee, Jordanian Food & Drug Administration
(JFDA), (Mar 2013-present)
Nanotechnology Committee, The University of Jordan, (Oct 2013-present)
References:
Professor Catherine J. Murphy (PhD advisor); phone: 217-333-7680; email:
murphycj@illinois.edu
University of Illinois at Urbana-Champaign
A521 Chemical & Life Sciences Laboratory
600 South Mathews Avenue
Urbana, IL (USA) 61801
Professor Mike Wyatt (PhD committee member); phone: 803-777-0856
wyatt@cop.sc.edu
University of South Carolina
College of Pharmacy
Room 515A, Coker Life Sciences Building
Columbia, SC (USA) 29208
Professor Steven Zimmerman (PhD committee member); phone 217-244-5943
sczimmer@illinois.edu
University of Illinois at Urbana-Champaign
A521 Chemical & Life Sciences Laboratory
600 South Mathews Avenue
Urbana, IL (USA) 61801
Professor R. William Caldwell (postdoctoral research mentor); phone: 706-721-2347
wcaldwel@georgiahealth.edu
Chairman, Pharmacology & Toxicology department
Georgia Regents University
1459 Laney Walker Blvd (CB-3530)
Augusta, GA (USA) 30912
Professor Rula Darwish (Dean of the Faculty of Pharmacy), phone: 00962-79-555-8089
rulad@ju.edu.jo;
Faculty of Pharmacy
The University of Jordan
Amman 11942-Jordan
Достижения и награды
“Speaker recognition award”, Faculty of Pharmacy, The University of Jordan, Sep 2014,
Amman, Jordan.
JPA Recognition Award, 2012, Jordan Pharmaceutical Association (JPA), Amman,
Jordan.
Recipient NIH/NHLBI Post-Doctoral Research Training Grant in Integrative
Cardiovascular Biology, 2010, Georgia Heath Sciences University, Augusta, Georgia,
USA.
Recipient USC Graduate School Research Award, 2007, University of South Carolina,
Columbia, South Carolina, USA.
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